Mushroom protein bar may improve cognitive function and memory
Researchers from Thailand designed a functional snack bar containing cone mushroom (Termitomyces fuliginosus) protein, to assess its effects on cognitive markers in middle-aged volunteers through a randomized double-blind placebo-controlled trial.
They aimed to investigate the medicinal properties of Termitomyces mushrooms and address the rising prevalence of cognitive impairment while meeting consumer demand for convenient, health-enhancing foods.
Mushrooms for cognitive health, memory support, and neuroprotection
Impaired cognitive function involves memory loss, learning difficulties, and reduced attention, which lower quality of life and increase the risk of dementia and mortality.
Global studies show rising rates of cognitive and memory issues, particularly in middle-aged and elderly populations.
The cone mushroom is common in Thailand and other Asian countries, and is rich in protein, dietary fiber, and bioactive compounds. When it comes to the nutritional benefits of Termitomyces, it has been shown to have antimicrobial, and antioxidant properties, and may offer neuroprotective and neuro-regenerative benefits.
Studies link edible mushrooms to improved mood, memory, and neurotransmitter levels, including acetylcholine and dopamine, which are crucial for cognitive function.
Termite mushrooms contain compounds like polysaccharides, flavonoids, and phenolics, including quercetin, that may combat oxidative stress and support brain health. However, few studies have explored the cognitive benefits of Termitomyces fuliginosus.
Clinical study finds neurotransmission benefits
The researchers developed a functional protein snack bar with cone mushroom protein, almonds, seeds, and fruits. This resulted in higher protein, dietary fiber, and amino acid levels than the mushroom protein concentrate alone.
Phytochemical analysis showed the bar had high flavonoid content, which correlated with strong antioxidant activity, confirmed by DPPH and ABTS inhibition tests.
A total of 26 middle-aged male and female participants were randomized and divided to receive placebo, FCM1 (a snack bar containing functional protein concentrate from cone mushroom at a dose of 1 g/serving/day), or FCM2 (a snack bar containing functional protein concentrate from cone mushroom at a dose of 2 g/serving/day).
Continuous consumption was performed for six weeks, and demographic data, body composition, cognitive function and memory were evaluated at baseline and at the end of the study period.
Baseline cognitive function tests revealed no significant differences, but after the intervention, brain wave activity associated with attention, sensory processing, cognitive processing and decision-making, showed improvement, pointing to improved cognitive function and memory in middle-aged adults.
The researchers suggest that the effects may be attributed to antioxidant activity and suppression of acetylcholinesterase (AChE) and monoamine oxidase (MAO), which play key roles in neurotransmission.
They also added that the product’s high dietary fiber may promote a beneficial gut-brain axis interaction, while its flavonoid content enhances neuroplasticity, brain blood flow, and antioxidant effects, all of which support cognitive health.
Further research is needed to explore the exact mechanisms, investigate neurotransmitter levels, and assess the product’s long-term effects on cognitive function in a larger population, the researchers concluded.
Source: Nutrients 2024, 16(21), 3616; https://doi.org/10.3390/nu16213616
“Effects of a Functional Cone Mushroom (Termitomyces fuliginosus) Protein Snack Bar on Cognitive Function in Middle Age: A Randomized Double-Blind Placebo-Controlled Trial”
Authors: Supaporn Muchimapura, S. et al.
