Berberine is associated with multiple benefits. However, its use and effectiveness has been limited by Its poor bioavailability resulting from low intestinal absorption. This issue has been overcome by developing Berberol®, an innovative patented formulation that combines berberine and silymarin. In numerous clinical studies the berberine-silymarin association has been shown to be more effective than berberine alone. Moreover, it has been confirmed that Berberol® reduces both glucose and lipid parameters with great efficiency, in the latter case also in synergistic association with statins.