Vitamin D is essential for calcium and bone metabolism and is mainly obtained from exposure to sunlight, with only low levels found in food and breast milk.
Risk factors for infant vitamin D deficiency — which can lead to the bone disorder rickets — include being exclusively breastfed, the research states.
Study co-author Dr Ben Wheeler, from the University of Otago, says many countries recommend giving babies daily vitamin D supplements during breastfeeding, but this advice is often not followed.
“We wanted to see if having mothers take a monthly, high-dose supplement could offer another way to help infants get sufficient levels of the vitamin,” Dr Wheeler says.
In a randomised controlled trial, 90 pregnant women who indicated that they intended to exclusively breastfeed for six months were divided into two supplementation groups and a placebo group.
Four weeks after birth, mothers in one supplementation group were given a 1.25mg dose each month for four months while women in the other group took a 2.5mg dose.
The babies’ vitamin D levels were measured from their cord blood or blood tests at the beginning of the trial and then assessed again at its end.
The researchers then adjusted for which season the babies were born in, their skin colour and whether they had been fed supplemented infant formula.
Deficiency protection
Compared to the placebo group, they found a significant and clinically meaningful increase in vitamin D levels in the blood of infants whose mothers took the highest dose.
“At this dose, the improvement in vitamin D status appears to offer some protection against moderate to severe deficiency in infants, as only one of the babies in the 2.5mg group showed serious deficiency compared to six in the placebo group,” Dr Wheeler says.
Dr Wheeler adds that there is growing concern internationally that the number of children suffering from vitamin D deficiency is increasing.
“If further research confirms our study’s findings then the next step would be to investigate how the monthly supplementation compares in effectiveness to mothers taking daily or weekly vitamin D doses,” he says.
The study findings appear in The Journal of Nutrition.
Source: The Journal of Nutrition
First published August 24, 2016, doi: 10.3945/jn.116.236679
“High-Dose Monthly Maternal Cholecalciferol Supplementation during Breastfeeding Affects Maternal and Infant Vitamin D Status at 5 Months Postpartum: A Randomized Controlled Trial”
Authors: Ben Wheeler, et al